Research > Team II:Structure-Based Drug Design Discovery

Name Jiafu Long
Research Area Understanding the mechanism of chromatin remodeling in the regulation of gene expression;
Protein complex assemblies in cell polarity establishment and maintenance;
The aberrantly regulated proteins in human disease;
Structure-based drug design and protein engineering for cancer therapy application
Tel 0086-22-23507159
Following finishing his undergraduate studies in Nankai University in 1999, China, Jiafu Long received his PhD degree of Biochemistry in 2004 for the works on the supramodular nature of neuronal scaffolding proteins in Mingjie Zhang’s lab (Hong Kong University of Science and Technology, Hong Kong) and subsequently carried out postdoctoral research in the same lab for three years. Then he begun independent research in Nankai University in 2007 as a specially-appointed Professor. In 2007, he was selected in the New Century Talent of the Ministry of Education of China. He is currently a Professor of Biochemistry and Molecular Biology in the College of Life Science and the State Key Laboratory of Medicinal Chemical Biology at Nankai University.
Resent Publications (in 5 years) 1. Wang Z, Yang X, Guo S, Yang Y, Su X-C, Shen Y*, Long J*. Crystal structure of the Ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism. J Biol Chem. 289(40): 27376-27385 (2014).
2. Chu X, Qin X, Xu H, Li L, Wang Z, Li F, Xie X, Zhou H, Shen Y*, Long J*. Structural insights into Paf1 complex assembly and histone binding. Nucleic Acids Res. 41(22): 10619-10629 (2013).
3. Xie X, Yang X, Wang Z, Zhou H, Diao W, Zhou W, Long J*, Shen Y*. Open-closed mechanism of Mint2 regulates APP metabolism. J Mol Cell Biol. 5(1): 48-56 (2013).
4. Lin Z, Zhao W, Diao W, Xie X, Wang Z, Zhang J, Shen Y*, Long J*. Crystal structure of Elongator subcomplex Elp4-6. J Biol Chem. 287(25): 21501-21508 (2012).
5. Zhang X, Chu X, Wang L, Wang H, Liang G, Zhang J, Long J*, Yang Z*. Rational design of a tetrameric Protein to enhance interactions between self-assembled fibers confers molecular hydrogels. Angew Chem Int Ed. 51(18): 4388-4392 (2012).