Research > Team II:Structure-Based Drug Design Discovery

Name Yue Chen
Research Area
Total Synthesis and Medicinal Chemistry of anti-CSC (Cancer Stem Cell) Natural Products
Tel 0086-22-23508090
Yue Chen obtained his Ph.D. degree under the advisory of Prof Richard E. Taylor at University of Notre Dame, where he studied the total synthesis, conformation and SAR of anti-cancer natural product epothilones. Dr. Chen joined in Kosan Biosciences Inc. in July 2003, and he worked as a scientist in department of medicinal chemistry. Dr. Chen started his academic career at NankaiUniversity in 2008, he is currently a professor in College of Pharmacy and the State Key Laboratory of Medicinal Chemical Biology.
Resent Publications (in 5 years)
1.   Feng Sang, Dongmei Li, Xiaolong Sun, Xianqiang Cao, Liang Wang, Jianlei Sun, Bingxia Sun, Lingling Wu, Guang Yang, Xiaoqian Chu, Jinghan Wang, Changming Dong, Yan Geng, Hong Jiang, Haibo Long, Sijia Chen, Guiyan Wang, Shuzhong Zhang, Quan Zhang, and Yue Chen*, Total Synthesis and Determination of the Absolute Configuration of Rakicidin A, J. Am. Chem. Soc.2014, Online, DOI: 10.1021/ja509379j.
2.   Jing Long, Shan-Feng Zhang, Pan-Pan Wang, Xue-Mei Zhang, Zhong-Jin Yang, Quan Zhang* and Yue Chen*, Total syntheses of parthenolide and its analogs with macrocyclic stereocontrol J. Med. Chem. 2014, 57, 7098–7112.
3.   Xiyan Duan, Yongliang Cui, Yue Chen, Xianglei Kong, Intramolecular oxo-Diels–Alder rearrangement in collisionally activated dissociation of protonated ions of a mactrocyclic molecule: triazole-epothilone dimer, J Mass Spectrom. 2014, 49, 755–762.
4.   Emilie Viennois, Bo Xiao, Saravanan Ayyadurai, Lixin Wang, Peng G Wang, Quan Zhang, Yue Chen, Didier Merlin, Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer, Lab. Invest. 2014, 1–16.
5.   Ningning Li, Yingtong Xu, Qiang Xian, Cuigai Bai, Taiyi Wang, Lei Wang, Dingdi He, Nannan Xie, Lixin Li, Jiang Wang, Hong-Gang Zhou, Feng Xu, Cheng Yang, Quan Zhang, Zheng Yin*, Yu Guo*, Yue Chen*, Simplified captopril analogues as NDM-1 inhibitors, Bioorg.Med. Chem. Lett. 2014, 24, 386–389.