Research > Team I:Molecular Mechanisms of Diseases and Target

Name Zheng Yin
Research Area Utilizing Organic chemistry, Chemical Biology and Proteomics, our research team investigates the innovative drugs and the novel drug development technology targeted several human causative virus.
Tel 0086-22-23500963
Zheng Yin obtained his BS and Master degrees in Chemistry from Nankai University, Tianjin, China, in 1994 and 1997, respectively. He then finished his PhD degree in Organic chemistry in National University of Singapore, Singapore, in 2000. He joined S*BIO Pte Ltd in Singapore in 2000 as a Dean and worked in Novartis Institute for Tropical Disease in 2004.He moved back to China in 2009 and joined the faculty of Nankai University, Tianjin. Currently, he is a Professor in the College of Pharmacy and a member of the State Key Laboratory of Medicinal Chemical Biology at Nankai University
Resent Publications (in 5 years)
1.    Biochemical characterization of recombinant Enterovirus 71 3C protease with fluorogenic model peptide substrates and development of a biochemical assay. L.-Q. Shang, S.-M. Zhang, X. Yang, J.-X. Sun, L.-F. Li, Z.-J. Cui, Q.-H. He, Y. Guo, Y.-N. Sun*, Z. Yin*, Antimicrob. Agents. Chemother. 2015 Apr;59(4):1827-1836.
2.    Site-Specific Chemical Modification of Peptide and Protein by Thiazolidinediones. Peng Wang , Shumei Zhang , Qiuyue Meng , Ying Liu , Luqing Shang *, and Zheng Yin*, Org. Lett., 2015, 17 (6), pp 1361–1364.
3.    Structure-guided Discovery of a Novel Non-peptide Inhibitor of Dengue Virus NS2B-NS3 Protease. Li L, Basavannacharya C, Chan KW, Shang L *, Vasudevan SG*, Yin Z*. Chem Biol Drug Des. 2014 Dec 23. doi: 10.1111/cbdd.12500.
4.    Anti-Dengue-Virus activity and structure–activity relationship studies of lycorine derivatives. P. Wang, L.-F. Li, Q.-Y. Wang, L.-Q. Shang*, P-Y., Shi*, Z. Yin*, ChemMedChem. 2014,9,1522-1533.
5.    Simplified captopril analogues as NDM-1 inhibitors. N.-N. Li, Y.-T. Yu, Q. Xia, C.-G. Bai, T.-Y. Wang, L. Wang, D.-D. He, N.-N. Xie, L.-X. Li, J. Wang, H.-G. Zhou, F. Xu, C. Yang, Q. Zhang, Z. Yin*, Y. Guo*, Y. Chen*, Bioorg.Med.Chem. Lett., 2014, 24 (1): 386-389.