Research > Team I:Molecular Mechanisms of Diseases and Target

Name Jun Zhou
Research Area
Cytoskeletal basis and signaling mechanism of human diseases and novel approaches to disease diagnosis and therapy
1) Regulation of cellular structures and processes by microtubules and related signaling proteins;
2) Functions of microtubules and related signaling proteins in the pathogenesis of human diseases;
3) Novel materials and methods for biomedical studies and clinical applications
Tel 0086-22-23504946

Jun Zhou received his bachelor's degree in Genetics from Fudan University in 1997 and then was a master's student in Cell Biology at Peking University. He went to the United States in 1999 and received his Ph.D. degree in Biochemistry,Cell and Developmental Biology from Emory University in 2002.He then worked at Genentech Inc as a postdoctoral fellow and at Emory University as an Instructor. He returned to China in 2005 to take a Professor position in the Department of Genetics and Cell Biology at Nankai University College of Life Sciences. He was a Visiting Professor in the Department of Biomedical Engineering at the Georgia Institute of Technology in 2014.Dr. Jun Zhou received the National Science Fund for Distinguished Young Scholars in 2008 and the Fok Ying Tung Young Faculty Award in 2010. He is a council member of the Chinese Society for Cell Biology and the Genetics Society of China. He serves on the editorial board of ActaPharmacologicaSinica and the editorial advisory board of Recent Patents on Anti-Cancer Drug Discovery. 

Resent Publications (in 5 years)
1.      Yang Y, Liu M, Li D, Ran J, Gao J, Suo S, Sun SC, Zhou J. (2014). CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation. PNAS 111(6):2158-2163.
2.      Yang Y, Ran J, Liu M, Li D, Li Y, Shi X, Meng D, Pan J, Ou G, Aneja R, Sun SC, Zhou J. (2014). CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6. Cell Research 24(11):1342-1353.
3.      Gao J, Sun L, Huo L, Liu M, Li D, Zhou J. (2010). CYLD regulates angiogenesis by mediating vascular endothelial cell migration. Blood 115(20):4130-4137.
4.      Sun L, Gao J, Dong X, Liu M, Li D, Shi X, Dong JT, Lu X, Liu C, Zhou J. (2008). EB1 promotes Aurora-B kinase activity through blocking its inactivation by protein phosphatase 2A. PNAS 105(20): 7153-7158.
5.      Liu M, Li D, Sun L, Chen J, Sun X, Zhang L, Huo L, Zhou J. (2014). Modulation of Eg5 activity contributes to mitotic spindle checkpoint activation and Tat-mediated apoptosis in CD4-positive T-lymphocytes. Journal of Pathology 233(2):138-147.