Research > Team I:Molecular Mechanisms of Diseases and Target



Name Rong Xiang
Research Area 1. The molecular mechanism of mutual regulation between tumor microenvironment and tumor stem cells and the role of tumor stem cell in tumor metastasis and recurrence.
2. High throughput screening of tumor stem cell-specific small molecule drugs and tumor targeted therapy by nanoparticle as drug carriers.
3. Novel design and preparation of DNA vaccine against tumor and tumor associated macrophage(TAMs) and the molecular mechanism of antitumor fusion protein against cancer.
Tel 0086-22-23509505
E-mail rxiang@nankai.edu.cn
Brief
Introduction
Education:

1992 -- Ph.D. -- Cell Biology and Experimental Nuclear Medicine, Shanghai Second Medical University, Shanghai 200025, China.
1989 -- M.M.Sc. -- Clinical Biochemistry, Chongqing Medical College, Chongqing 400062, Sichuan, China.
1982 -- M.D. -- Chongqing Medical College, Chongqing 400062, Sichuan, China.

Professional Experience:

2007-present: Distinguished Professor, Dean, Doctoral Mentor, Changjiang Scholar, School of Medicine, Nankai University, Tianjin, China.
2007-present: Director, Municipal Key Laboratory of Tumor Microenvironment and Tumor Stem Cells, Tianjin, China.
2008-present: Investigator, Department of Immunology, The Scripps Research Institute, La Jolla, California, USA.
2007-2008: Associate Professor, Department of Immunology, The Scripps Research Institute, La Jolla, California, USA.
2001-2007: Assistant Professor, Department of Immunology, The Scripps Research Institute, La Jolla, California, USA.
1999-2001: Senior Research Associate, Department of Immunology, The Scripps Research Institute, La Jolla, California, USA.
1996-1999: Research Associate, Department of Immunology, The Scripps Research Institute, La Jolla, California, USA.
1992-1996: Assistant, Associate Professor, Shanghai Medical University, Shanghai, China.
Resent Publications (in 5 years)
1.        Chen SLi XLu DXu YMou WWang LChen YLiu YLi XLi LYLiu     LStupack DReisfeld RAXiang RLi N. SOX2 regulates apoptosis through MAP4K4-Survivin signaling pathway in human lung cancer cells. Carcinogenesis. 2014 Mar; 35(3):613-23.
2.         Yeh DW, Liu YL, Lo YC, Yuh CH, Yu GY, Lo JF, Luo Y, Xiang R, Chuang TH. Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish. Proc Natl Acad Sci U S A. 2013 Dec 17 ;110(51):20711-6.
3.         Bai N, Zhang C, Liang N, Zhang Z, Chang A, Yin J, Li Z, Luo N, Tan X, Luo N, Luo Y, Xiang RLi X, Reisfeld RA, Stupack D, Lv D, Liu C. Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53. Cancer Biol Ther. 2013 Jun; 14(6):511-20.
4.         Liu Z, Lv D, Liu S, Gong J, Wang D, Xiong M, Chen X, Xiang RTan X. Alginic acid-coated chitosan nanoparticles loaded with legumain DNA vaccine: effect against breast cancer in mice. PLoS One. 2013;8(4) :e60190.
5.         Li XXu YChen YChen SJia XSun TLiu YLi X,Xiang RLi N. SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network. Cancer Lett. 2013 Aug ; 19;336(2):379-89.