Research > Team I:Molecular Mechanisms of Diseases and Target



Name Jintang Dong
Research Area Molecular mechanisms underlying the development and progression of human cancer.
Tel 0086-22-23506205
E-mail jtdong@nankai.edu.cn
Brief
Introduction
07.1989 – 10.1990: Assistant Investigator, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, China

10.1990 – 09.1994: Postdoctoral Visiting Fellow, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina

10.1994 – 09.1996: Postdoctoral Fellow, Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland

10.1996 – 06.2001: Assistant Professor, Department of Pathology (Primary appointment), Department of Biochemistry and Molecular Genetics (secondary appointment), University of Virginia School of Medicine, Charlottesville, Virginia

07.2001 – 03. 2002: Associate Professor, Department of Pathology (Primary appointment), Department of Biochemistry and Molecular Genetics (secondary appointment), University of Virginia School of Medicine, Charlottesville, Virginia

04.2002 – 08.2007: Associate Professor (with tenure), Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia.
Resent Publications (in 5 years)
(1)          Li X, Zhang B, Wu Q, Ci X, Zhao R, Zhang Z, Xia S, Su D, Chen J, Ma G, Fu L, and Dong JT (2014) Interruption of KLF5 acetylation converts its function from tumor suppressor to tumor promoter in prostate cancer cells. Int J Cancer 136(3):536-546.
(2)          Sun X, Fu X, Li J, Xing C, Frierson HF, Wu H, Ding X, Ju T, Cummings RD, Dong JT (2014) Deletion of atbf1/zfhx3 in mouse prostate causes neoplastic lesions, likely by attenuation of membrane and secretory proteins and multiple signaling pathways. Neoplasia. 16(5):377-89.
(3)          Sakata N, Kaneko S, Ikeno S, Yutaka M, Nakabayashi H, Dong XY, Dong JT, Tamaki T, Nakano N, and Itoh S (2014) TGFbeta signaling cooperates with AT motif-binding factor-1 (ATBF1) for repression of the alpha-fetoprotein promote. J Signal Transduct 2014:970346 (11 pages).
(4)          Xing C, Ci X, Sun X, Fu X, Zhang Z, Dong EN, Hao ZZ, and Dong JT (2014) Klf5 deletion promotes Pten deletion-initiated luminal type mouse prostate tumors via multiple oncogenic signaling pathways. Neoplasia 16(11):883-899.
(5)          Ci X, Xing C, Zhang B, Zhang Z, Ni JJ, Zhou W, and Dong JT (2015) KLF5 inhibits angiogenesis in PTEN-deficient prostate cancer by attenuating AKT activation and subsequent HIF1alpha accumulation. Mol Cancer 14:91 (15 pages)