Research > Team I:Molecular Mechanisms of Diseases and Target

Name Quan Chen
Research Area 1 The Role of Mitochondria in the Regulation of Programmed Cell Death: The role of Bcl-2 and its family proteins in cell death;
2 Mitochondrial quality control and diseases: Molecular regulation of mitochondrial dynamics (fission, fusion and mitophagy) and diseases
Tel 0086-22-23502962
Quan Chen obtained a BS degree in Biology from Hubei University, Wuhan, China, in 1985 a Master degree in Cytogenetics in Kunming Institute of Zoology, and Ph.D. in Cell Biology in the institute of Zoology, Chinese Academy of Sciences. Subsequently, he worked as postdoctoral fellow in the School of Biological Sciences, Manchester University in UK from 1994-1997; and in the Lerner Research Institute, Cleveland Clinic Foundation in USA from 1997 to 2000. He joined the State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences asa Professor in 2000, Professor and vice director, The State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences(2006- 2011).He is currently a Professor in College of Life Sciences at Nankai University.
Resent Publications (in 5 years)
1. Chen G, Han Z., Feng D, Chen YF, Chen LB, Wu H, Huang L, Zhou CQ, Cai XY, Fu CY, Duan LW, Wang XH, Liu L, Liu XQ, Shen YQ, Zhu YS*, Chen, Q*. A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy. Molecular Cell, 54: 362-377, 2014.
2. Yue W, Chen ZH, Liu HY, Yan C, Chen M, Feng D, Yan C, Wu H, Du L, Wang YY, Liu JH, Huang XH, Xia LX, Liu L., Wang XH., Jin HJ, Wang J, Song ZY, Hao XJ*, Chen Q*. A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30. Cell Research, 24(4):482-96, 2014.
3. Du L, Rao G, Wang H, Li B, Tian W, Cui JT, He L, Laffin B, Tian X, Hao C, Liu H, Sun X, Zhu Y, Tang DG, Mehrpour M, Lu Y*, Chen Q*.(2013) CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer, Cancer Research, 73(8): 2682-2694 (cover).
4. Rao G, Wang H, Li B, Huang L, Xue D, Wang X, Jin H, Wang J, Zhu Y, Lu Y, Du L*, Chen Q*, (2013) Reciprocal Interactions between Tumor-Associated Macrophages and CD44-Positive Cancer Cells via Osteopontin/CD44 Promote Tumorigenicity in Colorectal Cancer. Clinical Cancer Research.2013,Feb.15, 19(4):785-97
5. Lei Liu, Du Feng, Guo Chen, Ming Chen, Qiaoxia Zheng, Pingping Song, Qi Ma, Chongzhuo Zhu, Rui Wang, Wanjun Qi, Lei Huang, Peng Xue, Baowei Li, Xiaohui Wang, Haijing Jin, Jun Wang, Fuquan Yang, Pingsheng Liu, Yushan Zhu, Senfang Sui & Quan Chen*,(2012)Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells,Nature Cell Biology, 2012, Feb 14 (2):177-185