Research > Team II:Structure-Based Drug Design Discovery

Name Lihong Ye
Research Area Mechanism of the development of tumor and screening new drugs of anti-cancer
Tel 0086-22-23501385
Lihong Ye obtained a BS degree in Medicine from China Medical University, Shenyang, China, in 1983, an MSc degree in Pharmacology from Yanbian University, Yanji, china, in 1989, and a PhD degree from Gunma University, Maebashi, Japan, in 1997, also in Pharmacology. Having completed her postdoctoral training at Gunma University, she joined the faculty of Nankai University College of Life Sciences in 2000 as a Professor of Biochemistry, Tianjin, China. She is currently a Professor of Biochemistry and Molecular Biology in the College of Life Sciences, and Principle Investigator of the State Key Laboratory of Medicinal Chemical Biology at Nankai University.
Resent Publications (in 5 years) 1. Zhang T, Zhang J, You X, Liu Q, Du Y, Gao Y, Shan C, Kong G, Ye LH* and Zhang XD*. Hepatitis B Virus X Protein. (HBx) Modulates Oncogene YAP via CREB to Promote Growth of Hepatoma Cells. Hepatology, 2012, 56: 2051-9. (IF=11)
2. Shan C, Xu FQ, Zhang S, You JC, You XN, Qiu LY, Zheng J, Ye LH*, Zhang XD*. Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2. Cell Res. 2010, 20:563-75. (IF=11.98)
3. Qiao L, Xu Z, Zhao T, Zhao Z, Shi M, Zhao C, Ye LH*, Zhang XD*. Depression of tumorigenesis mediated by human mesenchymal stem cells in a model of hepatoma cells. Cell Res. 2008, 18:500-507. (IF=11.98)
4. Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, Sun B, Ye L*, Zhang XD*. Long Noncoding RNA HULC Modulates Abnormal Lipid Metabolism in Hepatoma Cells through an miR-9-Mediated RXRA Signaling Pathway. Cancer Res. 2015, 75(5):846-57. (IF=9.28)
5. Liu FB, You XN, Wang Y, Liu Q, Liu YX, Zhang SQ, Chen LY, Zhang XD, Ye LH*. The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF. Carcinogenesis. 2014, 35:1144-53. (IF=5.3)