Research > Team I:Molecular Mechanisms of Diseases and Target

Name Lin Liu
Research Area
Liu laboratory has been interested in reproductive aging and egg senescence, molecular mechanisms underlying early embryo development and differentiation, telomere biology, and derivation and understanding biology of patient-specific stem cells (e.g. parthenogenetic and induced pluripotent stem cells) that might be useful for regenerative medicine, particularly for treatment of reproductive aging and associated diseases.
Tel 0086-22-23500752
Lin Liu received B.S. degree in 1984 in Animal Science and Medicine, M.S. in Physiology and Biochemistry from Jiangxi Agricultural University, Doctorate degree in 1993 in Reproductive Biology and Biotechnology from Beijing Agricultural University (now China Agricultural University). He was a visiting scholar at the BBSRC Babraham Institute, Cambridge, UK, 1994-1996 and then did two year post-doctorate training in Cornell University and University of Connecticut, USA, 1996-1998. He worked as an Investigator and Assistant Professor at Women & Infants Hospital/Brown Medical School, 1998-2004. He was Professor at Sun Yat-sen University, Guangzhou, 2004-2007, currently is Professor in Nankai University, since 2007. He was Adjunct Assistant Scientist at Marine Biological Laboratory, 1998-2009, Visiting Faculty at the University of South Florida College of Medicine, and Member of H Lee Moffitt Cancer Center & Research Institute.
Resent Publications (in 5 years)
1.   Sung LY, Chang WF, Zhang Q, Liu CC, Liou JY, Chang CC, Ou-Yang H, Guo RP, Fu HF, TK Cheng, Ding ST, Chen CM, Okuka M, Keefe DL, Chen YE, Liu L, Xu J. Telomere elongation and naïve pluripotent stem cells achieved from telomerase haplo-insufficient cells by somatic cell nuclear transfer. Cell Reports 9:1603–1609 (2014).
2.   Dan J, Y Liu, N Liu, M Chiourea, M Okuka, T Wu, X Ye,C Mou, LWang, LL Wang, Y Yin, J Yuan, B Zuo, F Wang, Z Li, XPan, ZYin, L Chen, DL Keefe,S Gagos, A Xiao, Liu L. Rif1 maintains telomere length homeostasis of ES cells by mediating heterochromatin silencing. Developmental Cell 29: 7–19 (2014).
3.   Liu M, Yin Y, Ye X, Zeng M, Zhao Q, Keefe DL, Liu L. Resveratrol protects against age-associated infertility in mice. Human Reproduction 28:707-717 (2013).
4.   Wang F, Yin Y, Ye X, Liu K, Zhu H, Wang L, Chiourea M, Okuka M, Ji G, Dan J, Zuo B, Li M, Zhang Q, Liu N, Chen L, Pan X, Gagos S, Keefe DL, Liu L. Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells. Cell Research 22:757-768 (2012).
5.  Agarwal S, Loh YH, McLoughlin EM, Huang J, Park IH, Miller JD, Huo H, Okuka M, Dos Reis RM, Loewer S, Ng HH, Keefe DL, Goldman FD, Klingelhutz AJ, Liu L, Daley GQ. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature 464:292-296 (2010).