Research > Team I:Molecular Mechanisms of Diseases and Target

Name Xinyi Lv
Research Area Stem cell biology and aging-related fields
Xinyi Lv obtained hisbachelor degree in Biological Sciences from Nanyang Technological University, Singapore, in 2008. He did his National University of Singapore, attached to Genome Institute of Singapore, from 2008 to 2013. After that, he continued his post-doctoral training in Genome Institute of Singapore until 2015.He is currently a principal investigatorin the State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy at Nankai University.
Resent Publications (in 5 years)
1. Xinyi Lu, Friedrich Sachs, LeeAnn Ramsay,Pierre-Étienne Jacques, Jonathan Göke, Guillaume Bourque#& Huck-Hui Ng#. The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity. Nature Structural & Molecular Biology. 2014 Apr;21(4):423-5.
2. Xinyi Lu*, Jonathan Göke*, Friedrich Sachs, Pierre-Étienne Jacques, Hongqing Liang, Bo Feng, Guillaume Bourque, Paula A. Bubulya, Huck-Hui Ng#. SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells. Nature Cell Biology. 2013 Oct;15(10):1141-52.
3. JonathanGöke#, Xinyi Lu,Yun-Shen Chan, Huck-Hui Ng, Lam-Ha Ly, Friedrich Sachs, Iwona Szczerbinska. Dynamic transcription of distinct classes of endogenous retroviral elements marks specific populations of early human embryonic cells.Cell Stem Cell,2015 Feb; 16(2):135-141.
4. Yun-Shen Chan*, Jonathan Göke*, Jia-Hui Ng*, Xinyi Lu, Kevin Andrew Uy Gonzales, Cheng-Peow Tan, Wei-QuanTng, Zhong-Zhi Hong, Yee-Siang Lim, Huck-Hui Ng#. Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast. Cell Stem Cell. 2013 Dec;13(6):663-75.
5. Yun-Shen Chan, Jonathan Göke, Xinyi Lu, NandiniVenkatesan, Bo Feng, I-hsin Su, Huck-Hui Ng#. A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming. Stem Cells. 2013 Apr;31(4):682-92.