Research > Team I:Molecular Mechanisms of Diseases and Target

Name Luyuan Li
Research Area Tumor microenvironment
Vascular Cell Biology
Tel 0086-22-23502787
Luyuan Li obtained a BS degree in Biochemistry from Sichuan University, Chengdu, China, in 1982, and a PhD degree from Cornell University, New York, the United States in 1988, also in Biochemistry. Having completed his postdoctoral training at Pennsylvania State University, he joined American Cyanamid Company in New York in 1991 as a Senior Scientist. He moved back to academia to join the faculty of Georgetown University Medical Center, Washington, DC, in 1995, as an Assistant Professor of Biochemistry and Molecular Biology, and a Member of the Lombardi Cancer Center. He moved to University of Pittsburgh School of Medicine in 2002 as an Associate Professor of Pathology, Member of the University of Pittsburgh Cancer Institute, and Member of McGowan Institute for Regenerative Medicine. He moved his laboratory to China in 2008 and joined the faculty of Nankai University, Tianjin. He is currently a Professor of Pharmacology in the College of Pharmacy, and Director of the State Key Laboratory of Medicinal Chemical Biology at Nankai University.
Resent Publications (in 5 years)
1.      Zou, H, Thomas, SM, Yan, ZW, Grandis, JR, Vogt, A, and Li, LY. Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells. FASEBJ, 23(2):425-32, 2009
2.      Tian, F, Liang, PH, Li, LY. Inhibition of endothelial progenitor cell differentiation by VEGI. Blood 113:5352-5360, 2009
3.      Deng W, Gu X, Lu Y, Gu C, Zheng Y, Zhang Z, Chen L, Yao Z, Li LY. Down-modulation of TNFSF15 in ovarian cancer by VEGF and MCP-1 is a pre-requisite for tumor neovascularization. Angiogenesis, 2012, 15:71-85.
4.      JW Qi, TT Qin, LX Xu, K Zhang, GL Yang, J Li, HY Xiao, ZS Zhang*, LY Li* . TNFSF15 inhibits vasculogenesis by regulating relative levels of membrane-bound and soluble isoforms of VEGF receptor 1. Proc. Natl. Acad. Sci. USA, 110:13863-13868, 2013
5.      Z Zhou, F Liu, Z-S Zhang, F Shu, Y Zheng, Li Fu*, and L-Y Li*. Human rhomboid family-1 (RHBDF1) suppresses oxygen-independent degradation of hypoxia-inducible factor-1α in breast cancer. Cancer Res. doi: 10.1158/0008-5472.CAN-13-1027, 2014