Research > Team III:Drug Delivery Bio-Analysis & Bio-Imaging

Name Lehui Xiao
Research Area
In Xiao Lab we are applying and developing optical microscopic methods to explore problems in analytical chemistry, biomedicine and nanoscience. One of our main focus areas is the understanding of those ambiguous vital biological processes with functionalized nanomaterials in living cell with high spatial and temporal resolution. Meanwhile, we also interest in the exploration of the fundamental photophysical properties of novel functional nanomaterials and their potential applications in analytical chemistry for ultrasensitive detection. As our main tool, we are currently adopting single molecule/nanoparticle imaging and spectroscopy techniques to study the cellular uptake mechanisms of drug delivery nanocargos and their fate inside living cells, the substrate induced photophysical variation of organic molecules and the nonlinear optical response of novel functional nanomaterials.
2016.05—now Nankai University ,China
2013.12—2016.04 (full professor),Hunan Normal University ,China
2012.03—2013.12 ( lecturer)Hunan Normal University,China
2011.12—2012.09 (post doctor)University of Washington,U.S.A.
2011.01—2011.12 ( post doctor)Ames Laboratory,Department of Energy, U.S.A.
2008.05—2009.02( visiting scholar)Hong Kong Baptist University, Hong Kong
Resent Publications (in 5 years)
1. Wei, L.; Ma, Y.; Shi, X.; Wang, Y.; Su, X.; Yu. C.; Xiang, S.; Xiao, L.*; Chen, B.* Living Cell Intracellular Temperature Imaging with Biocompatible Dye-Conjugated Carbon Dots. J. Mater. Chem. B, 2017, 5, 3383-3390.
2. Su, X.; Li, Z.; Yan, X.; Wang, L.; Zhou, X.; Wei, L.; Xiao, L.*; Yu, C.* Telomerase Activity Detection with Amplification-Free Single Molecule Stochastic Binding Assay. Anal. Chem., 2017, 89, 3576-3582.

3. Wei, L.; Ye, Z.; Xu, Y.; Chen, B.; Yeung, E. S.; Xiao, L.* Single Particle Tracking of Peptides-Modified Nanocargo on Lipid Membrane Reveals Bulk-Mediated Diffusion. Anal. Chem., 2016, 88, 11973-11977.
4. Poon, C.; Wei, L.; Xu, Y.; Chen, B.; Xiao, L.*; Li, H.* Quantification of Cancer Biomarkers in Serum Using Scattering-Based Quantitative Single Particle Intensity Measurement with a Dark-Field Microscope. Anal. Chem., 2016, 88, 8849-8856.
5. Ma, Y.; Zhang, Z.; Xu, Y.; Ma, M.; Chen, B.; Wei, L.; Xiao, L.* A Bright Carbon-dot-based Fluorescent Probe for Selective and Sensitive Detection of Mercury Ions. Talanta, 2016, 161, 476-481.