Research > Team II:Structure-Based Drug Design Discovery

Name Wei Zhao
Research Area Carbohydrate-based vaccines, drugs and immunotherapy, as well as the structural and mechanism-based design and synthesis of inhibitors and ligands.
Tel 02285358083
Dr. Wei Zhao obtained his BS in Chemistry (1999) from Shandong University and his Ph.D. in Environmental Chemistry (2005) from the Research Center for Eco-Environmental Sciences (RCEES), CAS, Beijing. After he held postdoctoral fellowships at the Department of Chemistry, Tsinghua University with Prof. Yanmei Li in 2007, Dr. Zhao moved to the College of Pharmacy at Nankai University. Dr. Zhao is currently a professor in the College of Pharmacy at Nankai University. As a visiting scholor, he worked at the Department of Biochemistry, The Ohio State University with Prof. Peng G. Wang in 2009, and the Center for Cancer Research at Frederick, National Cancer Institute in 2010.
Resent Publications (in 5 years)

1. Guoqiang Zhang, Hongzhen Jin, Yunyan Zhao, Lina Guo, Xue Gao, Xiaoxue Wang, Shiyang Tie, Jie Shen, Peng George Wang, Hao Gan*, Huifei Cui*, Wei Zhao*, An efficient anticoagulant candidate: Characterization, synthesis and in vivo study of a fondaparinux analogue Rrt1.17,European Journal of Medicinal Chemistry, 2017, 126, 1039-1055.

2. Yonghui Liu,Wenpeng Zhang, Qianqian He, Fan Yu, Tianbang Song,Tingting Liu, Zhenqing Zhang, Jun Zhou, Peng George Wang* and Wei Zhao*,“Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines”. Chemical Communications, 2016, 52, 10886 - 10889.

3. Yonghui Liu, Tianbang Song, Weijia Meng, Yun Xu, Peng George Wang, Wei Zhao*,“Hafnium(IV) triflate as a highly efficient catalyst for Ferrier rearrangement of O- and S-nucleophiles with glycals”, Tetrahedron Letters. 2016, 25,2758–2762.

4.Jiajia Wang, Xiaomin Wang, Yunyan Zhao, Xiaoyao Ma, Yue Wan, Zhongwei Chen, Hao Chen, Hao Gan, Jing Li, Lei Li, Peng George Wang and Wei Zhao*,“Synthesis and biological evaluation of D-gluconhydroximo-1,5-lactam and its oxime-substituted derivatives as pharmacological chaperones for the treatment of Gaucher disease”,Med. Chem. Commun, 2016, 7, 365.

5. Lei Li, Yonghui Liu, Tiehai Li, Wenjun Wang, Zaikuan Yu, Cheng Ma, Jingyao Qu, Wei Zhao, Xi Chen and Peng G. Wang*, Efficient chemoenzymatic synthesis of novel galacto-N-biose derivatives and their sialylated forms”,Chem. Commun,2015,51, 10310-10313.