Research > Team I:Molecular Mechanisms of Diseases and Target



Name Chenggang Li
Research Area To investigate molecular mechanisms underlying the pathogenesis of lymphangioleiomyomatosis (LAM) caused by mutations in either TSC1 or TSC2 gene.
Using established preclinical models, we expect to define the mechanisms through which abnormal metabolic products will influence the survival and metastases of TSC2-deficient mTORC1 hyperactive cells, determine the unique metabolic signature, and evaluate the efficacy of targeted therapies in regression of established lung lesions. The "next steps" could include testing of candidate metabolomic profiles in animal with tumor burden; Phase I/II clinical trialsusing clinical approved drugs; and pre-clinical studies of their effects lung physiological improvements.
Our innovative approaches include a noninvasive real-time monitoring of tumor development and metastases in vivo using of bioluminescent imaging, the metabolomics profiling analyses, and the physiological function analyses in preclinical models.
Tel 022-85358317
E-mail lichenggang@nankai.edu.cn
Brief
Introduction
1. 2000—2002Nankai University
2002--2007 Harbin Medical University 7-Year Program
2. 2007--2011Peking Union Medical College Ph.D.


1.Fellowship Award:Estradiol and mTORC2 orchestrate to enhance prostaglandin biosynthesis and tumorigenesis in LAM. The LAM Foundation 2014, United State
2.Francis G. Byrnes Conference Awards:The LAM Foundation 2014, United State
Resent Publications (in 5 years)
  1. Chenggang Li, Po-Shun Lee, Yang Sun, Xiaoxiao Gu, Erik Zhang, Yanan Guo, Chin-Lee Wu, Neil Auricchio, Carmen Priolo, Jing Li, Alfredo Csibi, Andrey Parkhitko, Tasha Morrison, Anna Planaguma, Shamsah Kazani, Elliot Israel, Kai-Feng Xu, Elizabeth Petri Henske, John Blenis, Bruce Levy, David Kwiatkowski, Jane Yu. Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in tuberous sclerosis complex. The Journal of Experimental Medicine (JEM).2014 Jan 13;211(1):15-28 PMID: 24395886, PMCID: PMC3892971
  2. Chenggang Li, Penghui Yang, Yang Sun, Taisheng Li, Zhong Wang, Zhen Zou, Chen Wang, Zhongwei Chen, Li Xing, Chong Tang, Xiangwu Ju, Feng Guo, Jiejie Deng, Yan Zhao, Yiwu Yan, Peng Yang, Jun Tang, Zhinan Yin, Dangsheng Li, Bin Cao, Chen Wang, Xiliang Wang, Chengyu Jiang. IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus. Cell Research. 2011: 1-11. PMID: 22025253 PMCID: PMC3292301
  3. Sun Y, Guo F, Zou Z, Li C (co-first author), Hong X, Zhao Y, Wang C, Wang H, Liu H, Yang P, Han Z, Liu K, Kuba K, Song B, Gao J, Mo Z, Li D, Li B, Li Q, Zhong N, Wang C, Penninger JM, Jiang C. Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice. Particle and Fibre Toxicology 12 (4)  
  4. Yang Sun, Chenggang Li (co-1st author), Yuelong Shu, Xiangwu Ju, Zhen Zou, Hongliang Wang, Shuan Rao, Feng Guo, Haolin Liu, Wenlong Nan, Yan Zhao, Yiwu Yan, Jun Tang, Chen Zhao, Peng Yang, Kangtai Liu, Shunxin Wang, Huijun Lu, Xiao Li, Lei Tan, Rongbao Gao, Jingdong Song, Xiang Gao, Xinlun Tian, Yingzhi Qin, Kai-Feng Xu, Dangsheng Li, Ningyi Jin, and Chengyu Jiang. Inhibition of autophagy ameliorates acute lung injury caused by avian influenza A H5N1 infection. SCIENCE SIGNALING. 2012 Feb 21;5(212):ra16. PMID: 22355189
 5. Chenggang Li,Haolin Liu, Yang Sun, Hongliang Wang, Feng Guo, Shuan Rao, Jiejie Deng, Yanli Zhang,Yufa Miao, Chenying Guo, Jie Meng, Xiping Chen, Limin Li, Dangsheng Li, Haiyan Xu, Heng Wang, Bo Li, Chengyu Jiang. PAMAM Nanoparticles Promote Acute Lung Injury by Inducing Autophagic Cell Death through the Akt-TSC2-mTOR Signaling Pathway. JOURNAL OF MOLECULAR CELL BIOLOGY.2009 (1), 37-45, PMID: 19516051.